BRILLIANT-Rehab

Infrastructure and Program

Theme 1: Building the Mobility Profile

Currently no reliable measure exists to jointly evaluate the myriad of intrinsic and extrinsic factors that influence mobility for individuals with ABI. For the most part, to measure mobility in research, we rely on expensive laboratory technologies and performance-based tools that are burdensome in terms of set up, as well as staff time for administration and analysis. Importantly, these tools cannot be readily applied in real-life community contexts.

Further, electronic platforms that can collect real-time patient- and clinician-reported data are in their infancy, particularly in rehabilitation. The objective of theme 1 is to aggregate data from different types of rehabilitation technologies to evaluate the complex interplay between biomedical, personal and environmental factors that explain variability in mobility. This will be the first time this combination of technologies will be used to generate and validate mobility data that combines brain imaging, biomedical, patient reported and clinical measures. This will be accomplished within patient cohorts followed through the continuum of care and into the community (up to 2 years post ABI), enabling us to integrate and analyse their synergistic relationships.

Theme 1 Activities

Building The Mobility Profile

Portable

Mobility

Instruments

Activity: Development and validation of community-based portable mobility instruments

Moving in community environments is challenging for people with mobility restrictions as they must adapt to constantly changing contextual/environmental demands. Current laboratory and clinically-based evaluations of mobility do not sufficiently capture individuals’ capacity and performance as experienced in the community. We plan to develop and validate community-based portable mobility instruments to address this gap.

Researchers involved:

Dr. Philippe Archambault
Principal Investigator
Dr. Audrey Durand
Principal Investigator
Dr. Anouk Lamontagne
Principal Investigator
Dr. Sylvie Nadeau
Principal Investigator
Dr. Joelle Pineau
Principal Investigator

Patient

Reported

Outcomes

Activity: Participant Outcome Reporting Research System: Creating computerized adaptive tests (CATs) of Participant Reported Outcomes (PROs) for mobility-related domains

Participant reported outcome (PRO) data are crucial for understanding mobility as they enable researchers to measure factors influencing mobility that can only be provided by the individual participants. The greatest challenge to collecting PROs in the laboratory, clinical and community setting, however, is the length of time and repetitiveness of standardized paper-based measures, as well as their lack of precision and sensitivity to change. We plan to create computerized adaptive tests (CATs) of PROs for mobility-related domains.

Researchers involved:

Dr. Sara Ahmed
Principal Investigator, Scientific Director, BRILLIANT
Dr. Claudine Auger
Principal Investigator
Dr. Annette Majnemer
Principal Investigator
Dr. Claude Sicotte
Principal Investigator

Clinician

Reported

Outcomes

Activity: Clinical Research System to gather Clinician Reported Outcomes (ClinRo) from clinical research sites

Data captured at the point of rehabilitation care will provide information on performance-based measures of mobility and  rehabilitation interventions. We will leverage this work to identify strategies to optimize implementation of the Clinical Research System, including the added value of mobility data for clinicians to identify which interventions are optimal for specific patient sub-groups and to support clinical decision making.

Researchers involved:

Dr. Sara Ahmed
Principal Investigator, Scientific Director, BRILLIANT
Dr. Claudine Auger
Principal Investigator
Dr. Annette Majnemer
Principal Investigator
Dr. Claude Sicotte
Principal Investigator
Dr. Bonnie Swaine
Principal Investigator

Data &

Predictive

Analytics

Activity: Monitoring data to build the mobility profile

The BRILLIANT-Rehab Program will generate and pool biological biomedical data and PROs data collected using the PRO Research System with Clinician reported (ClinRo) data using the Clinical Research System and brain imaging (BrImagO) data acquired using Magnetic Resonance Imaging (MRI) during the acute, rehabilitation and community reintegration phases.

Researchers involved:

Dr. Sara Ahmed
Principal Investigator, Scientific Director, BRILLIANT
Dr. Audrey Durand
Principal Investigator
Dr. Joelle Pineau
Principal Investigator
Dr. Alain Ptito
Principal Investigator

BRILLIANT

Biomedical Research and Informatics Living Laboratory
for Innovative Advances of New Technologies